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Clinical Evidence Supporting Combination Therapies of Senolytic and Senomorphic Agents Clinical Translation and Challenges in the Development of Senolytic and Senomorphic Therapies The clinical translation of senolytic and senomorphic therapies is a promising but challenging endeavor

[1] FDA, Warning Letters, available at: (last visited: Sep

While previous reviews have often addressed these approaches separately, our synthesis brings together the most recent preclinical and clinical evidence, elucidates how oxidative stress is mechanistically linked to SASP activation, and critically evaluates pharmacokinetic and bioavailability challenges that influence therapeutic translation